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Cleverson de Souza

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Review Sep 2026

Matching genomic evidence to claims about Mycobacterium avium subsp. paratuberculosis: Host association, host adaptation, mechanism, and virulence.

Whole-genome sequencing (WGS) permits high-resolution comparison of Mycobacterium avium subsp. paratuberculosis (MAP) isolates and pangenome analysis. Combined with animal-movement data, WGS can support transmission inference, but resolution alone does not establish the biological meaning of genomic variation. This foc...

Cleverson de Souza · 0 citations
Open access Jul 2026

Metric discordance under MIDOG++ domain shift: a leave-one-domain-out audit of F1, emitted-detection confidence calibration, and ROI count error

Background Mitotic-figure detectors are usually evaluated by detection accuracy, but use also depends on confidence and count reliability under domain shift. Methods We evaluated MIDOG++ with leave-one-domain-out testing across seven domains. Adaptive-bin detection expected calibration error (D-ECE1) measured the bin-m...

Cleverson de Souza · 0 citations
Review Aug 2026

Macrophage state and Mycobacterium avium subsp. paratuberculosis persistence in cattle: An evidence-to-claim framework.

The reviewed evidence supports disease-history- and stage-associated differences in macrophage responsiveness, dissociation between inflammatory signaling and viable MAP control in defined models, altered lipid and phagosomal/endosomal readouts, and bacterial determinants of intracellular fitness.

Cleverson de Souza · 0 citations
#protein folding Open access Sep 2026

Lipopolysaccharide induces a delayed iron-handling transcript pattern in primary bovine macrophages.

Objective To characterize the timing and between-cow consistency of iron-handling transcript changes after lipopolysaccharide (LPS) exposure in primary bovine monocyte-derived macrophages. Methods Macrophages from 5 adult Holstein donor cows were exposed to Escherichia coli LPS or PBS and profiled by RNA sequencing a...

Kevin Hall, Leah Dunston, Donghee Lee et al. · 0 citations

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