Author

Courtney K. Ellison

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Open access Mar 2026

A broad-spectrum phage-encoded mechanism to disarm bacterial type IV filaments

It is shown that despite originating from a P. aeruginosa-specific phage, Aqs1 can also disable T4 ATPase-dependent phenotypes across other pathogenic bacteria and homologous systems and provides a design template for broad-spectrum inhibitors of diverse bacterial virulence factors.

Nathan Roberge, Paankhi Dave, Véronique L. Taylor et al. · bioRxiv · 0 citations

#protein folding Open access Aug 2026

β-strand addition within tip initiation complexes licenses assembly of diverse type IV filaments

How PilC/PilY1 can be retained on the fiber tip under enormous tensile loads generated during mechanical shear and T4P retraction is explained and how diverse T4P systems employ β-strand addition to license fiber assembly is demonstrated.

Taylor J. Ellison, Zoey R. Litt, Justin N. Applegate et al. · Proceedings of the National... · 0 citations