People living with HIV (PLWH) on suppressive antiretroviral therapy (ART) can face non-AIDS complications, partially driven by chronic immune activation. To define immune perturbations during ART-suppressed viral infection, we performed longitudinal single-cell transcriptomic and plasma proteomic analyses of rhesus mac...
Maanasa Kaza, B. Varco-Merth, G. McElfresh et al.· Cell Reports· 0 citations
The majority of persons living with HIV-1 who discontinue antiretroviral therapy (ART) demonstrate viral rebound, but the tissue-level events that lead to rebound viremia remain poorly understood. Here we report the origin, dynamics, and correlates of viral rebound in 16 rhesus macaques (RMs) infected with molecularly...
Irena V. King, Malika Aid, Emek Kose et al.· Science Translational Medici...· 0 citations
Trans translational insights are provided into the engineering challenges associated with scalable production of broadly neutralizing antibodies and key considerations for developing accessible antibody-based interventions for pediatric HIV prevention are highlighted.
T. Tsekoa, Lusisizwe Kwezi, P. Pillay et al.· Frontiers in Pediatrics· 0 citations
The SNAb assay could successfully multiplex hemagglutinin molecules to quantify the predicted neutralization of twelve analytes simultaneously and did not show an overcounting or undercounting of neutralizing antibody titers.
Lindsay R. McManus, Qixin Wang, Kate S. Levine et al.· Journal of Immunology· 0 citations
We use cookies to run the site and, with your consent, for analytics and to show ads.
See our Cookie Policy.
