Author

D. Fidock

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Open access Aug 2026

Discovery of Sphaeriaurantins as Rapid-Acting Antiplasmodials with Dual Activity in Blood and Liver Stages

The rapid emergence of resistance in the malaria-causing protozoan Plasmodium falciparum has heightened the demand for treatments with novel modes of action. Having evolved to produce a myriad of structurally diverse natural products (NPs) as defenses against soil-dwelling parasites including protozoa, Actinomycetota s...

Chantal D. Bader, Jennifer E. Collins, Yue-Lan Li et al. · Journal of the American Chem... · 0 citations

Open access Aug 2026

Genomic surveillance reveals co-occurrence of Plasmodium falciparum drug resistance variants across diverse transmission settings in Ethiopia

The emergence of antimalarial drug resistance threatens malaria control and elimination efforts in Africa. Ethiopia, once a success story in case reduction, is now experiencing a resurgence. Here we examine key drug resistance genes (Pfmdr1, Pfcrt, Pfk13, Pfdhfr and Pfdhps) and mitochondrial genomes from 605 Plasmodium...

A. Letebo, L. Vanheer, Mengst Engdaw et al. · Nature Microbiology · 0 citations

#protein folding Open access Sep 2026

In vitro pharmacodynamics of the antimalarial drug cabamiquine

In vitro findings help contextualize why the clinically observed lag in parasite clearance may be temporally distinct from symptomatic improvement, including fever resolution, and present cabamiquine as a fast-acting, slow clearing antimalarial drug.

Claudia Demarta-Gatsi, J. Wallner, S. K. Dhingra et al. · Antimicrobial Agents and Che... · 0 citations