Objective: Cerebrospinal fluid (CSF)-derived DOPA decarboxylase (DDC) is a promising biomarker of synucleinopathy; however, its relevance in Alzheimer’s disease (AD)-risk cohorts remains unclear. Research suggests that DDC may index co-pathology contributing to neurodegeneration and memory dysfunction beyond AD patho...
Jordan Stiver, C. McDowell, Xin Wang et al.· Archives of Clinical Neurops...· 0 citations
SCC is related to AD biomarkers and accelerated cognitive decline in the earliest stages of PD, and may serve as an early marker of cognitive risk, especially among persons with greater AD‐ or PD‐related burden.
F. Lopez, Fareshte Erani, K. Bangen et al.· Annals of Clinical and Trans...· 0 citations
Metabolic alterations and dysregulated alternative RNA splicing are central layers of Alzheimer’s disease (AD) pathogenesis, yet whether and to what extent these changes are mechanistically linked in adult human neurons in the aging brain remains unclear. To assess this, we generated induced neurons (iNs) by direct con...
Larissa Traxler, Oliver Borgogno, Kylie Champion et al.· bioRxiv· 0 citations
PCA is associated with a distribution of NFT pathology that coincides with early predominant visuospatial impairment in EOAD generally and may moderate degree of visuospatial impairment in EOAD regardless of clinical syndrome.
Denis S. Smirnov, Sophie M. Dickinson, Melanie F Estrella et al.· Free neuropathology· 0 citations
Frontotemporal lobar degeneration (FTLD) is a common cause of early-onset dementias marked by progressive declines in behavior, cognition, and/or movement. FTLD neuropathologies, including TDP-43 proteinopathies and primary tauopathies, do not have reliable fluid biomarkers for in-vivo diagnosis nor biomarkers that dir...
H. Oh, J. Downer, Connor D. Dietz et al.· bioRxiv· 0 citations
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