Author

D. Loew

2 papers indexed here

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Open access Aug 2026

Interactions of LINE-1 ORF1p with proteins and chromatin suggest a role in neuronal physiology

ORF1p, a LINE-1-encoded protein, regulates chromatin accessibility, neuron-specific gene expression, and neurite morphology in post-mitotic neurons, revealing a physiological role for this retrotransposon protein in the brain.

Sandra Sinnassamy, Olivia Massiani Beaudoin, Bérangère Lombard et al. · Life Science Alliance · 0 citations

Aug 2026

Proton minibeam radiation therapy induces distinct metabolic and synaptic remodelling in rats with orthotopic glioblastoma.

PURPOSE Glioblastoma (GB) is an aggressive primary brain tumour with limited therapeutic options. Although radiotherapy (RT) remains a cornerstone of treatment, its efficacy is constrained by collateral damage to healthy brain tissue. Proton minibeam radiotherapy (pMBRT), a spatially fractionated modality, has shown pr...

L. Roncali, M. Riquelme-Pérez, R. G. Teles et al. · International Journal of Rad... · 0 citations