Open access
Interactions of LINE-1 ORF1p with proteins and chromatin suggest a role in neuronal physiology
Sandra Sinnassamy
Olivia Massiani Beaudoin
Bérangère Lombard
D. Loew
Tom Bonnifet
Magali Fradet
Héloïse Monnet
Thomas Caille
N. Servant
Rajiv L. Joshi
Julia Fuchs
Medicine
Abstract
ORF1p, a LINE-1-encoded protein, regulates chromatin accessibility, neuron-specific gene expression, and neurite morphology in post-mitotic neurons, revealing a physiological role for this retrotransposon protein in the brain.