ORF1p, a LINE-1-encoded protein, regulates chromatin accessibility, neuron-specific gene expression, and neurite morphology in post-mitotic neurons, revealing a physiological role for this retrotransposon protein in the brain.
Sandra Sinnassamy, Olivia Massiani Beaudoin, Bérangère Lombard et al.· Life Science Alliance· 0 citations
PURPOSE
Rhabdoid tumors (RTs) are highly aggressive pediatric cancers driven by the biallelic inactivation of the SMARCB1 tumor suppressor gene, the sole recurrent genetic alteration. SMARCB1 encodes a core subunit of the SWI/SNF chromatin remodeling complex; its loss disrupts epigenetic gene regulation, supporting the...
C. Chauvin, Ryszard Wimmer, Ludovica Brunetti et al.· Clinical Cancer Research· 0 citations
It is shown that facultative escape regions are self-sustaining compartments of active chromatin enriched in H3K27 acetylation and depleted in H3K27 methylation, with the magnitude of compartment strength scaling up with the degree of transcriptional activity on the inactive X chromosome.
Antonia Hauth, A. Loda, Nikolai S. Bykov et al.· bioRxiv· 0 citations
Unsupervised read-level differential analysis recovers established lncRNA biomarkers; uncovers new prognostic transposable-element reads in adrenocortical carcinoma and sarcomas; and extracts signals even from reads that fail to align.
Erkan Narmanli, Alexandre Lanau, Mara Neacsu et al.· bioRxiv· 0 citations
This approach uncovers epigenomic priming of basal cells in the mammary gland and captures the dynamics of basal-to-luminal transdifferentiation, suggesting that epigenomic and transcriptional remodeling do not occur in complete synchrony during cell-fate conversion.
Anna Schwager, Eve Moutaux, Adeline Durand et al.· Nature Biotechnology· 0 citations
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