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Simultaneous single-cell profiling of chromatin, transcriptome and surface markers with OneCell CUT&Tag captures epigenomic reprogramming.

Anna Schwager Eve Moutaux Adeline Durand Alexandra Van Keymeulen A. Viaene Mélanie Miranda Louisa Hadj Abed Simon Besson-Girard Marion Lambault Délia Dupré Grégoire Jouault Melissa Saichi J. Bertorello Simon Dumas Mathias Schwartz Marthe Laisné J. Marsolier M. Guthmann L. Bonneville Urvashi Chitnavis Déborah Bourc'his Elisabetta Marangoni N. Servant Cédric Blanpain L. Perié C. Vallot
Aug 2026 · Nature Biotechnology · 0 citations · 45 references
Medicine

TL;DR

This approach uncovers epigenomic priming of basal cells in the mammary gland and captures the dynamics of basal-to-luminal transdifferentiation, suggesting that epigenomic and transcriptional remodeling do not occur in complete synchrony during cell-fate conversion.

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