Author

L. Perié

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Open access Sep 2026

A combined program of induced stemness and differentiation in response to IFNγ drives acute myeloid leukaemia growth

How inflammation shapes acute myeloid leukaemia (AML) has come under scrutiny, as it may explain the disease’s resistance to immunotherapy approaches. IFNγ has emerged as a key cytokine with paradoxical roles in suppressing and supporting AML growth, and the fundamental question of how leukemic stem cells (LSCs) respon...

C. Pospori, A. Donada, Helena Boutzen et al. · bioRxiv · 0 citations

Open access Sep 2026

The Pentose Phosphate Pathway Regulates Myelo-Lymphoid Lineage Specification

Following infection, hematopoietic stem and progenitor cells (HSPCs) support immunity by increasing the rate of innate immune cell production but the metabolic cues that guide this process are unknown. To address this question, we combined in situ RNA barcoding and metabolomics approaches to perform metabolic state-fat...

J. Cosgrove, A. Donada, A. Lyne et al. · bioRxiv · 0 citations

Open access Aug 2026

Simultaneous single-cell profiling of chromatin, transcriptome and surface markers with OneCell CUT&Tag captures epigenomic reprogramming.

This approach uncovers epigenomic priming of basal cells in the mammary gland and captures the dynamics of basal-to-luminal transdifferentiation, suggesting that epigenomic and transcriptional remodeling do not occur in complete synchrony during cell-fate conversion.

Anna Schwager, Eve Moutaux, Adeline Durand et al. · Nature Biotechnology · 0 citations