Author

D. Okumu

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Open access Sep 2026

Vulnerability of triple negative breast cancer to daraxonrasib pan-RAS(on) inhibition

Inhibiting pan-RAS(on) RAS-GTP with daraxonrasib, alone or in combination with a MEK inhibitor, provides a new strategy for the treatment of TNBC that inhibits RTK activation of the RAS-RAF-MEK-ERK pathway and tumor proliferation.

Michael P. East, J. Olivares-Quintero, D. Okumu et al. · bioRxiv · 0 citations

Open access Aug 2026

Transcriptomic Profiling of Mouse Mammary Tumors Enables Prognostic and Predictive Biomarker Discovery for Human Breast Cancer.

Comparing of multiple computational approaches, including XGBoost, random forests, and support vector regression, showed that all methods successfully predicted survival outcomes, with Elastic Net offering the best performance and interpretability.

Matthew D. Sutcliffe, K. Mott, Tulay Yilmaz-Swenson et al. · Cancer Research · 0 citations