Aug 2026
BVL3572S inhibits HisC and AlaA, exploiting vitamin B6 dependency to kill Mycobacterium tuberculosis.
These findings establish BVL3572S as a promising lead compound acting through a previously unexploited, multitarget mechanism, and display strong synergy with the antitubercular drug D-cycloserine.
Zainab Edoo, Astrid Lenne-Delmotte, C. Grosse et al.
· Cell Chemical Biology · 0 citations