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Open access Aug 2026

Polygenic risk score for early identification of coronary artery disease in a real-world clinical setting within the Latvian patient population

Study objective Polygenic risk scores (PRS) are increasingly recognized for their potential to improve coronary artery disease (CAD) prediction beyond traditional clinical models. This study evaluated the utility of genome-wide association study (GWAS) - derived PRS and pathway-specific PRS (PS-PRS) in the Latvian popu...

E. Kanašniece, Elita Ozola, L. Bardina et al. · 0 citations
Open access Jul 2026

Detection of miRNA in chronic spontaneous urticaria patients - pilot study

Background Chronic spontaneous urticaria (CSU) is a heterogeneous immune-mediated disorder characterized by recurrent wheals and/or angioedema. Despite advances in understanding its pathogenesis, robust biomarkers for disease stratification remain lacking. MicroRNAs (miRNAs) are key post-transcriptional regulators impl...

Lāsma Lapiņa, Katrīna Daila Neiburga-Vīgante, L. Gailīte et al. · 0 citations
Open access Jul 2026

Abnormal ClC-3/TMEM9-mediated endosomal ion transport in CLCN3-associated neurodevelopmental disease

The results expand the genetic and clinical spectrum of CLCN3-related disease, provide a solid basis for genetic counseling, and uncover an unexpected link between gating-associated conformational changes and inhibition by TMEM9.

Maya M. Polovitskaya, T. Tkemaladze, L. Jensen et al. · 0 citations
Sep 2026

Monoallelic loss-of-function variants in ZNF536 are associated with a neurodevelopmental disorder with prominent behavioral features.

Clinical cohort findings that rare monoallelic LoF variants in ZNF536 underlie a genetic neurodevelopmental disorder characterized by developmental delay, autism, and behavioral dysregulation support a role for ZNF536 as a dosage-sensitive regulator of cortical development.

S. Hiatt, Wen-Jing Zhao, Zhong-Qing Wang et al. · 0 citations

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