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Open access Aug 2026

Adjuvant T-DM1 versus trastuzumab plus pertuzumab for residual disease after neoadjuvant dual HER2 blockade in HER2-positive early breast cancer: a multicenter real-world study

Despite the established benefit of adjuvant trastuzumab emtansine (T-DM1) over trastuzumab in HER2-positive early breast cancer (eBC) with residual disease after neoadjuvant chemotherapy plus HER2-targeted therapy, comparison of efficacy between T-DM1 and dual HER2 blockade (trastuzumab plus pertuzumab, HP) remai...

Yue-Ran Jia, Shi-Hao Liang, Wei Wu et al. · 0 citations
#protein folding Open access Sep 2026

Plasma multi-omics reveals molecular remodeling and prognostic biomarkers in advanced breast cancer treated with trastuzumab deruxtecan

Paired plasma multi-omics revealed T-DXd-associated proteomic and metabolic remodeling and the molecular patterns and PFS-associated biomarkers are hypothesis-generating and require validation in larger independent cohorts.

D. Sang, Wen-Yu Yang, Jin-Song Liu et al. · 0 citations

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