Author

D. Wachholz Junior

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Open access Jul 2026

CRISPR RNA-independent activation of Cas12a

It is shown that short RNAs can directly occupy the canonical crRNA-binding channel and trigger a catalytically competent trans cleavage state in the absence of PAM recognition or canonical R-loop formation.

I. Iwe, S. Singh, K. Guan et al. · medRxiv · 0 citations