Aug 2026
Propofol regulates SLC6A2 expression via NAT10-mediated ac4C modification to modulate excessive mitophagy and hippocampal neuron dysfunction in aged postoperative cognitive dysfunction.
In aged POCD mice, knockdown of SLC6A2 improved cognitive performance and reduced neuroinflammation, oxidative stress, and excessive mitophagy, and Targeting SLC6A2 may represent a potential therapeutic strategy for POCD.
Ran-Ran Xu, Dengbang Xu
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