Aug 2026· Naunyn-Schmiedeberg's Archives of Pharmacology· 0 citations· 29 references
Medicine
TL;DR
In aged POCD mice, knockdown of SLC6A2 improved cognitive performance and reduced neuroinflammation, oxidative stress, and excessive mitophagy, and Targeting SLC6A2 may represent a potential therapeutic strategy for POCD.
Postoperative cognitive dysfunction (POCD) is a common complication in elderly patients after major surgery. It delays postoperative recovery and increases the risk of neurodegenerative disorders. CaMKIIδ is a key calcium-signaling regulator of neuronal survival and neuroinflammation, yet its functional role in P...
Kai-Hua Wei, Shi-Wen Fan, Yu-Jia Zhao et al.· Frontiers in Aging Neuroscie...· 0 citations
Cerebral ischemia-reperfusion injury (CIRI) is a leading cause of neurological disability with few effective therapeutic strategies, and ferroptosis has been proven to participate in CIRI progression while its upstream regulatory mechanisms remain poorly defined. Herein, we performed transcriptomic analysis on GSE16207...
Hai-Ning Wang, Bai-Chao Han, Chen Xu et al.· Archives of Biochemistry and...· 0 citations
Background Sepsis-associated encephalopathy (SAE) is a syndrome of cerebral dysfunction secondary to sepsis. Although the α7 nicotinic acetylcholine receptor (α7nAChR) plays a pivotal role in the SAE, the specific mechanisms by which it mediates neuroinflammatory responses and contributes to pathological injury in SAE...
Yue-Song Liu, Fu-Hua Wang, Lu Wang et al.· Frontiers in Immunology· 0 citations
BACKGROUND
Cervical spondylotic myelopathy (CSM) involves progressive neurological dysfunction often linked to mitochondrial impairment. Mitophagy, a selective autophagic process, is crucial for neuronal homeostasis; however, its role in CSM and the specific involvement of AMPK subunits in TFEB-mediated mitophagy remai...
Pei-Min Pu, Yu-Xiang Dai, Shi-Pian Li et al.· Phytomedicine· 0 citations
