Author

Denis C. Guttridge

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Open access Sep 2026

Reassessing the Role of Progenitor Cells in Muscle Wasting in Cancer Cachexia.

Skeletal muscles contain myogenic and non-myogenic progenitor cells that proliferate and differentiate after tissue damage to restore myofiber, connective tissue, and blood vessel homeostasis. We previously showed that cancer-induced muscle wasting involves myofiber damage and impaired differentiation of myogenic proge...

Spencer G. Miller, Abasi-Ama Udeme, Emma Funk et al. · American Journal of Physiolo... · 0 citations

#protein folding Sep 2026

Abstract A062: SFRP2 Silencing Restrains Pancreatic Cancer Growth and Enhances Survival Through Remodeling of the Tumor Microenvironment

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy with limited therapeutic options. Secreted frizzled-related protein 2 (SFRP2) has emerged as an important mediator of tumor progression by promoting tumor cell survival, immune exhaustion, and angiogenesis. In human PDAC, elevated SFRP2 expressio...

Olivia Sweatt, Lillian Hsu, Lety Reyes Angeles et al. · Cancer Research · 0 citations