Author

Derek H. Oakley

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#protein folding Open access Oct 2026

Scalable proteomics with multiDIA resolves proteoforms in neurodegenerative disease

Deep proteome characterization has traditionally required multidimensional chromatographic fractionation, long acquisition times and large sample amounts, thus limiting scalability. Here, we introduce multiDIA, which combines independent digestions with multiple proteases and data-independent acquisition (DIA) to incre...

Orhun Kok, Corinna Friedrich, Kirsten Altig et al. · bioRxiv · 0 citations

Open access Aug 2026

Proteomic comparison of hippocampal neurofibrillary tangles in PART, intermediate Alzheimer’s disease and advanced Alzheimer’s disease

By addressing how Aβ accumulation alters the tangle proteome, this study provides mechanistic insights into the expansion of Tau pathology, paving the way towards the identification of biomarkers and therapeutic strategies that would allow for stabilisation of Tau pathology in the elderly.

Manon Thierry, D. Leitner, Kaleah Balcomb et al. · Acta Neuropathologica · 0 citations