Diego E Pafundo

NMDA receptor hypofunction on GABAergic interneurons results in input-specific Excitatory/Inhibitory imbalance in pyramidal neurons of medial prefrontal cortex

It is found that circuit dysfunction can selectively bias the processing of specific afferent pathways rather than produce a uniform disruption of cortical excitability, with direct relevance for understanding hippocampal–prefrontal dysconnectivity in neuropsychiatric disorders.