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Sponsored AI Networking Cookbook: Practical recipes for AI-assisted network automation and development AI Networking Cookbook: Practical recipes for AI-assisted network automation and development

Author

Donglin Yu

Peking university

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Open access Sep 2026

Transmembrane Protein PTCHD4 Is a Novel Regulator of Cellular Senescence and Age‐Related Pathologies

Cellular senescence is a key driver of age‐related pathologies. Our study focuses on PTCHD4, a transmembrane protein with previously undefined physiological functions in aging processes. We found that PTCHD4 expression was increased across multiple cellular senescence models and showed an age‐associated increase in mou...

Ming-Yue Wang, Zhao-Yun Yang, Qi-Kai Wang et al. · 0 citations
#gene editing Open access Sep 2026

Structure-guided discovery and engineering of miniature CRISPR-Cas12m for epigenome editing.

CRISPR-based epigenome editing represents a programmable strategy to precisely modulate gene expression, holding promise for therapeutic applications. However, the large size of dCas proteins substantially impedes delivery using adeno-associated virus (AAV) vectors. Here, through iterative bioinformatics analysis, stru...

Tao Yu, Meng Ji, Donglin Yu et al. · 0 citations
Open access Aug 2026

TAL1 is indispensable in ETV2-primed human endothelial cell fate determination

It is demonstrated that ETV2 drives the rapid forward programming of human pluripotent stem cells (hPSCs) into endothelial cells (ECs) by direct remodeling of endothelial-specific enhancers and is established as a master gatekeeper of human EC specification.

Yun Zhao, Mengze Sun, Zi-Xuan Hong et al. · 0 citations

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