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Sponsored AI Networking Cookbook: Practical recipes for AI-assisted network automation and development AI Networking Cookbook: Practical recipes for AI-assisted network automation and development

Author

Dorota Nowak

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Open access Sep 2026

PFKFB3 and PFKFB4 inhibition modulates the response of metabolically plastic resistant melanoma cells to BRAF/MEK-targeted therapy

Despite the development of selective inhibitors targeting oncogenic BRAF mutations, melanoma therapy remains limited by acquired resistance driven by multiple mechanisms, including metabolic reprogramming. PFKFB isoenzymes regulate cellular adaptation to therapeutic stress and may therefore represent promising th...

S. Trojan, B. Ostrowska, P. Kaczara et al. · 0 citations
Open access Aug 2026

Metabolism alterations accompany the invasive phenotype of melanoma cells resistant to BRAF/MEK inhibitors.

The obtained results suggest that the purpose of metabolic changes present in melanoma cells resistant to BRAF/MEK inhibitors is mainly to support the significantly increased invasiveness of these cells.

M. Kot, A. Simiczyjew, Katarzyna Pietraszek-Gremplewicz et al. · 0 citations

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