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Author

Duan-Qing Pei

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Open access Aug 2026

In vivo multimodal lineage tracing of mammalian development by DeepTrack barcoding

A comprehensive recording of cell fate transitions and underlying molecular changes remains a fundamental goal in developmental biology. Here, we present DeepTrack, a lineage tracing mouse model that integrates in situ cellular barcoding with high-throughput, single-cell multi-omics to simultaneously profile clonal fat...

Chen-Yu Guo, Jun-Yao Jiang, Xiaomin Wang et al. · 0 citations
Open access Aug 2026

Distinct regulation of Wnt signaling and EPZ5676 governs human UiPSM reprogramming via the CDX2/T/TBX6 core axis

An ideal in vitro system to study somitogenesis is induced presomitic mesoderm (UiPSM); the regulatory pathways of this system are not well understood. Here, integrated multi-omic and functional analyses were performed to elucidate the roles of Wnt signaling and EPZ5676 in UiPSM reprogramming. The findings showed that...

Kaipeng Wang, Xingnan Huang, Huiru Gao et al. · 0 citations
Jul 2026

A fast 2C-induction method reveals a barrier role of SP2 for totipotency

This study has established a highly efficient in vitro model for totipotency induction and highlighted molecular barriers shaping cell fate decisions, providing a platform to dissect the mechanisms governing the pluripotency-to-totipotency transition.

Siling Hu, Ping-Hui Zhu, He Liu et al. · 0 citations

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