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A fast 2C-induction method reveals a barrier role of SP2 for totipotency

Siling Hu Ping-Hui Zhu He Liu Huan Chen Shun-Lan Xu En-Jing Guo Baomei Cai Xiongzhi Quan Duan-Qing Pei Jiekai Chen Hao-Yu Wu Shang-Tao Cao
Jul 2026 · bioRxiv · 0 citations · 37 references
Biology

TL;DR

This study has established a highly efficient in vitro model for totipotency induction and highlighted molecular barriers shaping cell fate decisions, providing a platform to dissect the mechanisms governing the pluripotency-to-totipotency transition.

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