The Alzheimer’s disease risk gene ABCA7 regulates microglial lysosomal and lipid homeostasis and promotes phagocytosis to maintain neuronal health
Background Loss of function mutations in the lipid transporter ABCA7 have been linked to increased risk for late onset Alzheimer’s disease (AD). Although rare and common variants in ABCA7 associated with AD alter the coding sequence and are predicted to impair protein function, the precise cell-type consequences of ABC...
Sarah E. Heuer, Fasiha Ahsan, Gizem Terzioglu et al.
· bioRxiv · 0 citations