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This work integrates rare-variant analysis within the AM framework, highlights the potential interplay between variant types and establishes a novel strategy to guide future fine-mapping and causal variant identification in admixed populations.
Distinct metabolomic profiles were associated with incident PAD and CLI years before clinical onset, highlighting dysregulated glycemic control, impaired redox balance, and altered lipid remodeling as key underlying pathways and suggest that circulating metabolites may serve as early indicators of metabolic health rele...
This study illustrates that GWAS with high-scale imputation may still help to unravel the biological mechanism behind circulating lipid levels and identifies more new rare and low-frequency functional variants associated with circulating lipid levels.
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