Skip to content
Log in
Sponsored Design Multi-Agent AI Systems Using MCP and A2A: Engineer your own Pyt Design Multi-Agent AI Systems Using MCP and A2A: Engineer your own Pyt

Meta-analysis of 49(cid:0)549 individuals imputed with the 1000 Genomes Project reveals an exonic damaging variant in ANGPTL4 determining fasting TG levels

E. V. van Leeuwen A. Sabo J. Bis Jennifer E. Huffman A. Manichaikul A. Smith M. Feitosa S. Demissie Peter K. Joshi Q. Duan J. Marten J. V. van Klinken Ida Surakka I. Nolte Weihua Zhang H. Mbarek R. Li-Gao S. Trompet N. Verweij Evangelos Evangelou L. Lyytikäinen B. Tayo J. Deelen P. J. van der Most S. W. van der Laan D. Arking A. Morrison Abbas Dehghan Oscar H Franco A. Hofman F. Rivadeneira E. Sijbrands A. Uitterlinden J. Mychaleckyj A. Campbell L. Hocking S. Padmanabhan J. Brody T. Harris A. Isaacs Harry Campbell Leslie A. Lange I. Rudan I. Kolčić Pau Navarro T. Zemunik V. Salomaa The LifeLines C. Study Angad S. Kooner J. Kooner B. Lehne W. Scott Sian-Tsung Tan E. D. de Geus Y. Milaneschi H. Penninx G. Willemsen R. de Mutsert Ian Ford R. Gansevoort Marcelo P. Segura-Lepe O. Raitakari J. Viikari K. Nikus Terrence Forrester C. Mckenzie A. D. de Craen Hester M. de Ruijter G. Pasterkamp H. Snieder A. Oldehinkel P. Slagboom Richard S. Cooper M. Kähönen V. Vitart O. Polašek Caroline Hayward James G. Wilson James F. Wilson V. Gudnason Stephen S. Rich B. Psaty I. Borecki E. Boerwinkle Jerome I. Rotter L. Cupples C. V. van Duijn CMvD A. Cupples Cornelia M. van Gudnason Vilmundur James F. Wilson S. Ripatti Ko Willems Van Dijk A. M. McKenzie Hester M. de Craen De Ruijter Charge Lipids T. Olli Jorma S Raitakari Kjell Viikari Terrence Nikus C. Forrester Ian Renée de Mutsert Ron T Ford Marcelo P Gansevoort J. Segura-Lepe Yuri de Geus Brenda W J Milaneschi Eco Zemunik Kenneth M Sijbrands Oscar H Dehghan A. Franco Fernando Hofman Eric J Rivadeneira S. Most D. E. van der Laan Alanna Arking A. Morrison Leo-Pekka Bamidele O. Lyytikäinen J. Tayo Peter J Deelen van der Ruifang Stella Li-Gao Niek Trompet E. Verweij Evangelou Ida Klinken Ilja M. Surakka Weihua Nolte Hamdi Zhang Mbarek Peter K Demissie Qing Joshi Jonathan Duan J. Marten Ani van Huffman A. Manichaikul MaryKate Smith Serkalem Elisabeth M Feitosa A. van Leeuwen Joshua C Sabo Jennifer E. Bis
· 0 citations · 47 references

TL;DR

This study illustrates that GWAS with high-scale imputation may still help to unravel the biological mechanism behind circulating lipid levels and identifies more new rare and low-frequency functional variants associated with circulating lipid levels.

Semantic Scholar
View source

Similar papers

Review Open access Aug 2026

Suggestive genome-wide associations with inflammatory biomarkers in an admixed population, including a missense variant in the OR6K6 olfactory receptor gene associated with MCP-1

New SNPs linked to inflammatory biomarkers in a highly admixed Brazilian population are identified, including a missense variant in an olfactory receptor gene linked to MCP-1, which may be biologically important for inflammation and could affect the risk of cardiometabolic diseases.

J. Leite, G. F. L. Pascoal, G. B. S. Duarte et al. · 0 citations
Open access Aug 2026

Trans-ancestry meta-analysis of genome-wide association study identifies eight novel genetic loci in type 1 diabetes: A multi-population study.

BACKGROUND Type 1 diabetes (T1D) is a common disease. Although genome-wide association studies (GWASs) have identified hundreds of associated single nucleotide polymorphisms (SNPs), very few T1D GWAS have simultaneously addressed both Asian and European populations. METHODS Here, we conducted a large-scale trans-ance...

Xu-Ying Guo, Jingyan Hu, Hong-Sheng Tian et al. · 0 citations
Aug 2026

Evidence from European ancestry genome-wide association studies and a case-control study suggests several selenoproteins are linked to a decreased risk of Alzheimer's disease

Genetic and clinical evidence is provided that specific selenoproteins are associated with a decreased risk of AD and highlight the potential role of these proteins in AD pathophysiology and suggest their promise as biomarkers or therapeutic targets, warranting further investigation.

Pei-Xin Jiang, Si-Bo Peng, Yan-Ling Huang et al. · 0 citations
Meta-analysis Open access Aug 2026

Multi-population GWAS meta-analysis identifies bladder cancer susceptibility loci and highlights genetic regulation of smoking-related risk

A multi-population meta-analysis of genome-wide association studies, including 32,470 individuals with and 1,753,462 without bladder cancer, identifies 70 independent risk loci, of which 43 are novel, and uses experimental approaches to uncover how inherited variation influences this risk in the context of smoking.

L. Prokunina-Olsson, O. Flórez-Vargas, Michael G. Levin et al. · 0 citations
Open access Aug 2026

LPA genetic variation is associated with type 2 diabetes after adjustment for lipoprotein(a) concentration: results of the Aragon Workers’ health study

The findings suggest that common LPA variation represented by the 15-SNV genetic score may contribute to T2D risk through mechanisms not fully captured by circulating Lp(a) concentration alone.

P. Corredoira, Daniel Bello Álvarez, Itziar Lamiquiz Moneo et al. · 0 citations

We use cookies to run the site and, with your consent, for analytics and to show ads. See our Cookie Policy.