Author

I. Nolte

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Open access Sep 2026

Genome-wide analysis of social behaviour across social domains, reporters and developmental stages: a meta-regression approach.

Social behaviour is a heritable trait linked to well-being and mental health, yet it varies across social context, including social domains, informants and development, which may shape its underlying genomic architecture. Here, we conducted a genome-wide meta-regression meta-analysis of social behaviour from infancy to...

L. de Hoyos, Fenja Schlag, Sanjeevan Jahagirdar et al. · Nature Human Behaviour · 0 citations

Open access Aug 2026

Polygenic and familial contributions to antidepressant continuation, switching, discontinuation and augmentation in the All of Us and Pharmlines cohorts

Antidepressant switching partly indexes depression severity rather than drug-specific non-response alone, whereas augmentation captures cross-disorder psychiatric complexity, and familial aggregation was confined to sustained, switch-free continuation.

A. Walker, X. Wang, J. Bos et al. · medRxiv · 0 citations

Review Open access Aug 2026

SNPannotator: automated functional annotation of genetic variants and linked proxies

The SNPannotator package is introduced, an automated post-GWAS analysis software package designed to streamline the interpretation of GWAS findings and provide a practical framework for efficiently deriving biologically meaningful insights from GWAS data.

Alireza Ani, I. Nolte, Zoha Kamali et al. · Bioinformatics · 1 citation

Meta-analysis of 49(cid:0)549 individuals imputed with the 1000 Genomes Project reveals an exonic damaging variant in ANGPTL4 determining fasting TG levels

This study illustrates that GWAS with high-scale imputation may still help to unravel the biological mechanism behind circulating lipid levels and identifies more new rare and low-frequency functional variants associated with circulating lipid levels.

E. V. van Leeuwen, A. Sabo, J. Bis et al. · 0 citations