Author

S. Padmanabhan

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Clinical trial Open access Oct 2026

PHOENIX: a study protocol for a pilot randomised controlled trial of pre-emptive pharmacogenomic panel testing in acute care settings with health economic evaluations

Abstract Introduction Pharmacogenomic (PGx) panel testing may reduce adverse drug reactions (ADRs), treatment failures and downstream healthcare use by aligning prescribing with germline genetic variation. The PREPARE trial reported an approximately 30% reduction in clinically relevant ADRs using a pre-emptive multigen...

S. Lip, P. T. Pepler, A. McConnachie et al. · BMJ Open · 0 citations

Open access Aug 2026

Cardiometabolic pathways linking genetically proxied educational attainment to cardiovascular disease: a Mendelian randomisation, mediation and colocalisation study

Aims Socioeconomic disadvantage is associated with excess cardiovascular disease (CVD), but the extent to which this gradient operates through modifiable biological pathways remains unquantified. We used Mendelian randomisation (MR) to estimate how much of the association between genetically proxied educational attainm...

N. N. Le, S. Padmanabhan · medRxiv · 0 citations

Meta-analysis of 49(cid:0)549 individuals imputed with the 1000 Genomes Project reveals an exonic damaging variant in ANGPTL4 determining fasting TG levels

This study illustrates that GWAS with high-scale imputation may still help to unravel the biological mechanism behind circulating lipid levels and identifies more new rare and low-frequency functional variants associated with circulating lipid levels.

E. V. van Leeuwen, A. Sabo, J. Bis et al. · 0 citations