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Author

E. Comets

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2 papers indexed here

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Meta-analysis Open access Aug 2026

The effect of mefloquine dose on outcome of uncomplicated falciparum malaria treated with artesunate-mefloquine: a WWARN systematic review and individual patient data meta-analysis

A combination of mefloquine associated with artesunate (AS-MQ) was the first artemisinin-based combination therapy (ACT) to be used widely for acute uncomplicated P. falciparum malaria. Individual patient data from 31 studies of patients with uncomplicated falciparum malaria treated with various AS-MQ regimens (target...

E. Ashley, Emmanuel Baron, M. Bouyou-Akotet et al. · 0 citations
Preprint Sep 2026

PK/PD-integrated Bayesian platform design for phase II dose regimen optimization

A Bayesian phase II adaptive platform design for regimen optimization that integrates pharmacokinetic/pharmacodynamic (PK/PD) modelling into toxicity, efficacy, regimen selection and adaptation decisions is developed.

A. Vuorinen, A. Guillon, E. Comets et al. · 0 citations

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