Author

E. El-Helw

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Open access Sep 2026

Target-oriented synthesis of benzoquinoline-embedded candidates: antimicrobial potential and in silico insights

A new series of benzo[h]quinoline-based derivatives was synthesized using a thiocarbohydrazone scaffold as a versatile intermediate for the construction of diverse nitrogen- and sulfur-containing heterocycles, including tetrazine, thiadiazole, triazole, pyrazole, and thiadiazine motifs. These structural variations were...

E. El-Helw, Abeer M. El-Naggar, Mahmoud Kamal et al. · RSC Advances · 0 citations

Open access Sep 2026

Synthesis and in silico studies of hexahydroacridine derivatives as potential antitumor agents

The anticancer potential of newly synthesized hexahydro-1,8-acridinedione derivatives featuring strategic structural modifications at positions 9 and 10 is evaluated, establishing compound 4d as a promising multi-target lead scaffold, warranting further optimization toward selective anticancer therapeutics.

E. El-Helw, S. Hammad, Hassan A. Khatab et al. · Scientific Reports · 0 citations

Open access Jul 2026

Design, synthesis, biological assessment, and integrated computational analysis of new pyrazole-based antimicrobial candidates

These findings highlight pyrazole-based scaffolds as promising antimicrobial candidates with favorable biological profiles, providing a strong basis for further structural optimization.

E. El-Helw, Selwan Hamed, A. El-ziaty et al. · Scientific Reports · 1 citation

#protein folding Aug 2026

Benzo[h]quinoline-based heterocyclic derivatives as Culex pipiens larvicidal candidates: synthesis, bioactivity, biochemical response, and in silico mechanistic insights.

Biochemical evaluation of triazinone 3 revealed significant reductions in acetylcholinesterase activity and in total protein, carbohydrate, and lipid contents compared with untreated larvae, indicating that larval mortality was accompanied by cholinergic disturbance and depletion of metabolic reserves.

E. El-Helw, Mahmoud Kamal, Eslam M. Hosni et al. · Bioorganic chemistry (Print) · 0 citations