Author

E. Embaby

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Open access Sep 2026

Silymarin and Zinc Oxide Nanoparticles Attenuate Experimental Colon Cancer in Rats Through Crosstalk of miR-192 and β-Catenin Pathways

Colon cancer (CC) is a leading cause of cancer-related mortality globally. Although chemotherapy remains the primary treatment, its toxicity and drug resistance highlight the need for alternative therapeutic strategies. Silymarin (Sily), a natural compound, and zinc oxide nanoparticles (ZnO-NPs) have shown potential an...

Eman H. Yousef, Aya Megahed, A. Samy et al. · Biomolecules · 0 citations

Sep 2026

Empagliflozin shields brain from methotrexate toxicity: Nrf2/HO-1/GPX4 activation prevents ferroptosis and chemo-brain in rats.

BACKGROUND Methotrexate (MTX) can induce "chemo-brain," but mechanisms remain incompletely defined. Ferroptosis has been implicated in MTX toxicity. We investigated whether Empagliflozin (EMPA) protects against MTX-induced neurotoxicity by modulating ferroptosis-related pathways. METHODS Male Sprague-Dawley rats (n =...

Mohammad El-Nablaway, Hend M. Hassan, O. Erfan et al. · Tissue & Cell · 0 citations

Aug 2026

Nanoliposomal curcumin protects against D-galactose-induced hepatic aging by targeting oxidative stress, mitochondrial dysfunction, and inflammatory signaling.

CUR, especially in its nanoliposomal form, exerts potent hepatoprotective, antioxidant, anti-inflammatory, and anti-apoptotic effects against D-galactose-induced liver aging, supporting its potential as a therapeutic strategy for age-related hepatic dysfunction.

E. Elmorsy, Ayat B. Al-Ghafari, H. A. Al Doghaither et al. · The Journal of pharmacy and... · 0 citations