Author

E. Engelberg-Cook

2 papers indexed here

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Open access Sep 2026

TMEM106B is a selective modulator of TDP‐43 pathology in Alzheimer's disease

Co‐pathologies – including Lewy body, vascular, and TDP‐43 lesions – are common in Alzheimer's disease (AD), contributing to its clinical and pathological heterogeneity. Genetic risk factors may drive mixed pathology presentation, but their influence on the development of specific co‐pathologies remains unclear.

Madison M. Reeves, Anna Calliari, Tiffany W. Todd et al. · Alzheimer's & Dementia · 0 citations

Sep 2026

Cross-species single-cell atlas of the striatum defines cell-type and subregion disease vulnerabilities.

Using single-nucleus RNA sequencing across 109 human and 22 mouse samples spanning dorsal and ventral striatum, a comprehensive atlas of subregional neuronal specialization is provided, suggesting divergent pharmacological targets, connectivity, and disease mechanisms.

Raleigh M. Linville, Benjamin T. James, K. Galani et al. · Cell · 2 citations