Open access
TMEM106B is a selective modulator of TDP‐43 pathology in Alzheimer's disease
Madison M. Reeves
Anna Calliari
Tiffany W. Todd
Candela Maroto Cidfuentes
Karen R. Jansen-West
M. Yue
Yuping Song
J. Dunmore
Bailey D. Rawlinson
E. Engelberg-Cook
M. DeTure
Gregory S. Day
N. Graff-Radford
B. Boeve
D. Knopman
Ronald C. Petersen
Casey N. Cook
M. Murray
Dennis W. Dickson
K. Josephs
L. Petrucelli
Mercedes Prudencio
Medicine
Abstract
Co‐pathologies – including Lewy body, vascular, and TDP‐43 lesions – are common in Alzheimer's disease (AD), contributing to its clinical and pathological heterogeneity. Genetic risk factors may drive mixed pathology presentation, but their influence on the development of specific co‐pathologies remains unclear.