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The Alzheimer's disease risk gene SORL1 is a regulator of excitatory neuronal function

C. Williams Shannon E. Rose Vera Stamenković Aquene N. Reid K. Travaglini Stephen E. P. Smith Jessica E. Young

Sep 2026 · Alzheimer's & Dementia · Vol 22 · 0 citations · 70 references

Medicine

Abstract

Synaptic dysfunction is an early feature of Alzheimer's disease (AD) and proper localization of proteins involved in pre‐ and post‐synaptic composition is dependent on endosomal recycling and trafficking, cellular processes involving the AD risk gene sortilin‐related receptor 1 (SORL1).

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