Author

E. M. Fassi

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Open access Aug 2026

Structure-guided design of an LC3B-targeting PNA oligomer modulating autophagy and LC3B-mediated mRNA decay

Autophagy plays a central role in cellular degradation and recycling pathways, and the LC3B protein is essential for this process. Dysregulation of LC3B has been implicated in oncogenesis. In this study, we used a computational approach to design a novel peptide nucleic acid (PNA) targeting the RNA-binding domain of LC...

Marco Albani, E. M. A. Fassi, Alessandra Romanelli et al. · RSC Medicinal Chemistry · 0 citations

Aug 2026

AI-Driven Computational Design of Peptide-Based WWP1 Inhibitors as Promising Therapeutic Agents Against Breast Cancer, Including Triple-Negative Subtype

WI23-B is highlighted as a promising lead peptide with potent WWP1 inhibitory activity and synergistic antiproliferative effects when combined with PI3K inhibitors, and has the potential to reshape therapeutic strategies for BC and TNBC by enabling more effective and less toxic treatment regimens.

E. M. A. Fassi, Sara Mathlouthi, E. Maspero et al. · bioRxiv · 0 citations

#protein folding Open access Aug 2026

Protein language model-generated enzyme sequences exhibit high stability in molecular dynamics simulations

By combining conditional pre-trained language model fine-tuning with dynamic structural evaluation, the framework advances beyond static sequence-based predictions to address the structural and functional dimensions of enzyme behavior, key aspects for both biomedical and industrial applications.

E. M. A. Fassi, Marco Nicolini, Emanuele Saitto et al. · Frontiers in Artificial Inte... · 0 citations