Engineered mRNA nanostructures expand the design space of mRNA therapeutics through programmable protein expression and immune stimulation
Self-assembling mRNA origami (mRNA-OG), a class of unimolecular RNA nanostructures that encode protein-coding sequences within higher-order, programmable, and compact nucleic acid architectures, is developed and established as a new design parameter for mRNA therapeutics that can affect its functionality, delivery prop...
Mark D. Knappenberger, S. J. Henry, Archana Kikla et al.
· bioRxiv · 0 citations