Comparative protein engineering redirects the specificity of Clostridium botulinum proteases.
A comparative protein engineering strategy that integrates prior mutagenesis, bioinformatics, and structural insights to reprogram LC protease specificity is reported, establishing comparative protein engineering as an effective framework for retargeting botulinum neurotoxin proteases.
J. E. Garrido, G. S. Salcedo, Max W. Strul et al.
· Cell Chemical Biology · 0 citations