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Author

Emil Axell

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Open access Jul 2026

Galectin-3 drives tau-associated neuroinflammation, white matter degeneration and proteomic dysregulation

Galectin-3 is identified as a central upstream regulator linking tau pathology to neuroinflammation, proteomic dysregulation, mitochondrial dysfunction, and white matter degeneration andTargeting Gal3 represents a promising therapeutic strategy to mitigate tau-driven neurodegenerative processes.

Lluís Camprubí-Ferrer, Marzia Dell’Eva, Jesús Soldán-Hidalgo et al. · 0 citations
Open access Aug 2026

Human chaperone DNAJB6b suppresses tau fibril formation through co-aggregation

The authors study the impact of DNAJB6b on tau fibril formation, showing that it delays tau aggregation by co-assembling with small tau aggregates and by binding to mature fibrils, reducing their ability to catalyze further fibril growth.

Andreas Carlsson, Emil Axell, Johan Wallerstein et al. · 1 citation · ⚡1

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