Open access

Galectin-3 drives tau-associated neuroinflammation, white matter degeneration and proteomic dysregulation

Lluís Camprubí-Ferrer Marzia Dell’Eva Jesús Soldán-Hidalgo Alberto Lerma-Aguilera L. R. Rodríguez J. Frontiñán-Rubio Katryna Pampuščenko Emil Axell Erika Velásquez Yi-Yi Yang Henrik Ahlenius Juan García-Revilla J. Vitorica A. Boza-Serrano J. Venero T. Deierborg

Jul 2026 · bioRxiv · 0 citations

Biology

TL;DR

Galectin-3 is identified as a central upstream regulator linking tau pathology to neuroinflammation, proteomic dysregulation, mitochondrial dysfunction, and white matter degeneration andTargeting Gal3 represents a promising therapeutic strategy to mitigate tau-driven neurodegenerative processes.

DOI Semantic Scholar

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