F. Altemani

Bavachin Attenuates Cognitive Impairment in Scopolamine-Induced Amnesia: Behavioral, Biochemical and Molecular Insights.

Cholinergic dysfunction is a key feature of cognitive impairment, and currently available acetylcholinesterase (AChE) inhibitors provide limited symptomatic benefit and are often associated with adverse effects. This study evaluated the cognitive-protective effects of bavachin (BVC), a prenylated flavonoid from Psorale...

Immune cell-derived exosomes in the tumor microenvironment: mechanisms of immune evasion and emerging therapeutic strategies in cancer immunotherapy

Tumor-released exosomes have emerged from the shadows of “cellular dust” to be recognized as pivotal mediators of intercellular communication within the tumor microenvironment (TME). These nano-sized vesicles (30–150 nm) carry a complex cargo of proteins, lipids, and nucleic acids that profoundly reshape anti-tumor imm...

Anti-Inflammatory Role of Exopolysaccharides in Osteoarthritis via Modulation of Redox and Inflammatory/Catabolic Signaling Networks.

Mechanistic Insights into Honey-Mediated Antibacterial Activity Against Enterobacteriaceae: A Multifaceted Approach Targeting Membrane Integrity, Protein Synthesis, and Quorum Sensing Inhibition.

Findings establish honey as a multitarget antimicrobial agent operating through synergistic perturbation of membrane integrity, metabolic inhibition, and virulence attenuation, offering promising therapeutic potential against resistant Enterobacteriaceae.

Identification of novel and known variants in GAA, MYH6, NEXN, ATA3A, RHBDF1, and ACTA1 genes in coronary artery disease patients by Whole-exome sequencing

High-resolution exome sequencing allows the detection of pathogenic and likely pathogenic variants in critical genes associated with cardiovascular health and provides evidence of functional significance, thereby elucidating complex interactions between genetic factors and enhancing understanding of disease mechanisms.

Anti-nociceptive property of thymol: animal study with molecular docking and MD simulation studies

Overall, THY showed significant anti-nociceptive activity in vivo, while computational results suggest potential interaction with COX enzymes.

Paeonol as a Multi‐Target Therapy for Neurological Disorders: Mechanistic Insights Into Neuroprotection

Neurological disorders are a major global health challenge in the current era, and they need new therapeutic treatments.