Author

F. Drost

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Open access Aug 2026

Germline-encoded V(D)J gene usage does not impose strict constraints on the epitope-specificity of T cell receptors

Diversity of epitope-specific TCRs is not limited by distinct germline combinations, but rather can emerge from a near-to-complete combinatorial space of α- and β-chain, V and J segments paired with compatible CDR3 sequences.

Adrian Straub, Yang An, F. Drost et al. · bioRxiv · 0 citations