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Open access Sep 2026

Association of antifungal treatment duration with 90-day mortality in critically ill adults with candidemia: a multicenter target trial emulation in France

Summary Background The optimal duration of antifungal therapy for candidemia in intensive care unit (ICU) patients remains uncertain. We aimed to evaluate whether shorter antifungal therapy was not associated with increased mortality using a target trial emulation framework. Methods We conducted a multicenter cohort st...

F. Reizine, J. Henry, L. Desmedt et al. · 0 citations
#gene editing Sep 2026

A new MRR1 gain-of-function mutation involved in cross-resistance to antifungal agents in the fungal priority pathogen Candida parapsilosis.

The findings reinforce the central role of Mrr1 in antifungal resistance, underscore the functional diversity of its mutational landscape, and underscore the functional diversity of its mutational landscape, with potential implications for fungal fitness and transcriptional regulation.

Manon Cadeau, José Rivaldo de Lima, Alina Marcela-Sabou et al. · 0 citations

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