Author

F. van Petegem

2 papers indexed here

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Open access Oct 2026

Structural and kinetic mechanisms of state-dependent potassium channel inhibition

The KCNQ1 (Kv7.1) potassium ion (K+) channel plays a critical role in cardiac repolarization, while loss- or gain-of-function mutations increase the risk of life-threatening arrythmias and sudden death. Like many channels, KCNQ1 exhibits state-dependent pharmacological properties with inhibitors such as UCL2077 display...

E. Kyriakis, Agnese Roscioni, Jodene Eldstrom et al. · Science Advances · 0 citations

#protein folding Open access Sep 2026

A Seven Amino Acid Long Region in the Cardiac Cav1.2, Encompassing Ser1487, Is Essential for Mice Embryonic Development and “Fight or Flight” Responses

Highlights What are the main findings? A 7aa region in the proximal C-terminus is essential for embryonic development and the structural integrity of Cav1.2. Mutation of S1487 to alanine attenuates the increase in ICaL following β-adrenergic receptor stimulation in vitro and in vivo. What are the implications of the ma...

Cathy Jenkins, Henrietta Cserne Szappanos, A. Dyrda et al. · Cells · 0 citations