Malnourished children are susceptible to an increased risk of mortality owing to impaired immune functions. However, the underlying mechanism of altered immune functions and its interaction with malnutrition is poorly understood. This study investigates the immune function and evaluates the effect of a particular nutri...
Zannatun Noor, M. Hasan, Md. Amran Gazi et al.· Scandinavian Journal of Immu...· 6 citations
Abstract. Chronic exposure to infectious agents results in environmental enteric dysfunction—a significant contributor to childhood stunting. Low plasma tryptophan (TRP), increased kynurenine (KYN), and KYN–TRP (KT) ratio are associated with infections and chronic immune activation. We postulated that both these condit...
Md. Amran Gazi, Subhasish Das, M. A. Siddique et al.· American Journal of Tropical...· 26 citations· ⚡1
Background Environmental enteric dysfunction (EED) is thought to occur from persistent intestinal inflammation. Studies also revealed the association of lipocalin-2 (LCN2) and low-density lipoprotein receptor-related protein-1 (LRP1) with intestinal inflammation. Therefore, we intended to explore the relationship of LC...
M. Hasan, Md. Amran Gazi, Subhasish Das et al.· BMJ Paediatrics Open· 6 citations
Infections and persistent immunological activation are linked to increased kynurenine (KYN) and the KYN-to-Tryptophan (TRP) or KT ratio and may be critical factors in undernutrition. We sought to determine the association between the KT ratio and adult malnutrition, as well as investigate if nutritional supplementation...
Md. Amran Gazi, M. A. Siddique, M. Alam et al.· Nutrients· 4 citations
In the current world, a major challenge to diagnose environmental enteric dysfunction (EED) is the lack of validated non-invasive biomarkers. Intestine derived molecules, including intestinal fatty acid binding protein (I-FABP), trefoil factor-3 (TFF3), lactoferrin, lipocalin-2 (LCN2), and mucin-2, have been reported a...
M. Hasan, Md. Amran Gazi, Subhasish Das et al.· Scientific Reports· 12 citations· ⚡4
Fucosyltransferase 2 (FUT2) and 3 (FUT3) may influence host biological functions. We aim to assess the relationship between maternal and child FUT2 (Secretor) and FUT3 (Lewis) status with growth, body composition, gut health and histologic features in Bangladeshi children. We conducted a case–control study where secret...
Md. Amran Gazi, S. M. Fahim, M. Hasan et al.· Scientific Reports· 5 citations
Children suffering from severe acute malnutrition (SAM) have a weakened immune system. The relationship between malnutrition and alterations in the frequency of peripheral blood mononuclear cells (PBMCs) remains unclear. This study investigated the altered immune responses in Bangladeshi children with SAM compared to h...
Zannatun Noor, S. Islam, M. Hasan et al.· Immunobiology· 3 citations
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