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#protein folding Oct 2026

FAP-Triggered In Situ Self-Assembly of HPQ in Tumors Empowers 131I Internal Radiotherapy

Fibroblast activating protein (FAP) is specifically overexpressed in malignant tumors. The 2-(2′-hydroxyphenyl)-4(3H)-quinazolinone (HPQ) scaffold exhibits hydrophobicity, aggregation-induced emission (AIE). The responsive probes built on HPQ can undergo in situ activation and self-assembling precipitation, enabling...

Jiang Wu, Yan Hu, Guo-Qiang Zhou et al. · 0 citations
Aug 2026

An indocyanine green-potentiated gastrin releasing peptide receptor-targeting multifunctional peptide-drug conjugate for prostate cancer therapy.

It is suggested that rational ICG installation markedly elevates the functional competence of GRPR-targeted PDC, giving rise to an enhanced multifunctional therapeutic entity capable of diagnosis, image-guided surgery, and targeted treatment for PCa.

Hao Tian, Zihan Huang, Xiang-Ding Liu et al. · 0 citations

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