Author

François Dehez

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Open access Aug 2026

Deinococcus radiodurans HU: a versatile architect of nucleoid structure and plasticity

Nucleoid-associated proteins are known to compact and organise bacterial genomes, but how their local DNA binding shapes higher-order chromatin architecture remains unclear. Using in vitro and in situ approaches, we investigated how Deinococcus radiodurans HU (DrHU) orchestrates nucleoid organisation. DrHU engages DNA...

H. Bernhard, S. De Bonis, A. Banneville et al. · bioRxiv · 0 citations

#protein folding Open access Sep 2026

Breaking timescales with generative sampling of conformational transitions

Gen-COMPAS is introduced, a generative committor-guided path-sampling framework that reconstructs rare biomolecular transition pathways and reveals the underlying thermodynamics and kinetics without using predefined collective variables or brute-force sampling, at an acceptable computational cost.

Chen-Yu Tang, M. P. Pandey, Cheng Giuseppe Chen et al. · Nature · 3 citations