The central purpose of this article is to define a desired destination around which the field can organize scientific innovation, including validated biological staging, risk stratification, longitudinal biomarker trajectories, trial enrichment, preventive endpoints, regulatory qualification, scalable implementation, a...
Günther U. Höglinger, Franziska Hopfner· Journal of neural transmissi...· 0 citations
Ongoing research aims to establish sensitive biomarkers, identify prodromal disease stages, and develop targeted interventions addressing key pathophysiological mechanisms such as α-synuclein aggregation and neuroinflammation.
I. Wilkens, Sabrina Katzdobler, A. Bernhardt et al.· Fortschritte der Neurologie...· 1 citation
Bridging advances in pathophysiology with patient-centred care will be essential for improving outcomes in MSA, and advances in fluid biomarkers and multimodal imaging are expected to facilitate earlier detection, improve diagnostic accuracy, and provide more robust tools for monitoring disease progression.
J. Buonocore, Bianca Calió, Fabian Leys et al.· Journal of neural transmissi...· 0 citations
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