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Review Open access Sep 2026

[Stargardt disease: genetics, molecular mechanisms, potential lifestyle interventions and pharmacotherapy].

Stargardt disease (STGD1) is the most common inherited macular dystrophy. It is caused by biallelic variants in the ABCA4 gene and leads to impaired retinoid transport within photoreceptors. Disruption of retinoid clearance results in the accumulation of lipofuscin in the retinal pigment epithelium (RPE), which in turn...

T. Lipsky, Sophia Dithmar, G. Ansari et al. · 0 citations

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