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Author

G. Bange

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Open access Sep 2026

The diadenosine tetraphosphate hydrolase YqeK controls fitness, biofilm formation, staphyloxanthin production and virulence in Staphylococcus aureus

It is shown that AP4A is upregulated upon deletion of yqeK encoding the Ap4A hydrolase in S. aureus COL, and the ΔyqeK mutant was impaired in growth and survival during oxidative stress and after infection of murine macrophages, indicating that Ap4A contributes to the host-pathogen interactions in S. aureus.

Loi Van Vu, Sarah Przibilla, Fabiana Burchert et al. · 0 citations
Open access Aug 2026

Molecular insights into the promiscuous Ap4N hydrolase YqeK

These findings establish YqeK as a central regulator of dinucleotide homeostasis and RNA metabolism and provide the structural framework for Ap4N recognition by HD-domain phosphohydrolases.

Renuka Dharani Shivakumar, Natalie Happel, Fabiana Burchert et al. · 0 citations
Open access Aug 2026

Discovery of a Cell-Permeable Gi-Signaling Inhibitor

N-hydroxyapiosporamide (NHAP) is established as a first-in-class Gi-selective inhibitor, providing a cell-permeable chemical scaffold for the optimization of next-generation agents to control Gi-signaling in cell-based systems and, ultimately, to target Gαi1-driven pathologies.

A. Naimi, Tim Berger, Philipp Dahlhaus et al. · 0 citations

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